心血管

专家介绍 -- 副院长何国伟

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何国伟


姓名:何国伟(副院长)

科室:基础医学研究室/心外科

职称:主任医师/教授/博士生导师

学历:博士研究生


何国伟教授,现任泰达国际心血管病医院心血管外科主任医师兼基础医学研究中心主任。并兼任美国俄勒冈医学及科技大学医学院临床外科学教授,南开大学医学院外科学教授(2007-2012)。



早年获中国协和医科大学临床医学硕士学位,担任中国医学科学院北京阜外医院心血管外科主治医师,主管心血管外科病房。后由阜外医院派往澳大利亚进修心血管外科,在澳大利亚墨尔本皇家儿童医院进修小儿先天性心脏病外科,并在圣文森医院,Epworth医院进修冠心病搭桥及成人心外科,完成了系统的心血管外科训练,并于1988年获澳大利亚墨尔本莫纳西大学临床医学博士学位(后又于2003年因其科学工作获莫纳西大学科学博士 [Doctor of Science] 学位)。1988年后担任悉尼皇家阿尔费雷德医院心血管外科资深注册医生(Senior Registrar),从事心外科工作。于1990 年转往北美洲,先后任美国达拉斯及波特兰圣文森医院心脏外科临床客座教授(Visiting Professor,俄勒冈州license)及心脏血管研究主任。1995年,在香港大学的全球招聘中,在有美国及欧洲心外科医师作为应聘者的情况下,成功获聘为香港大学心脏外科首席(讲座)教授 (Chair Professor)。 后于2000-2009年转任香港中文大学研究讲座教授。 何国伟教授并被聘为其它多所大学的名誉教授或海外董事。



何国伟教授在数十年的行医生涯中,以病人的利益为第一位。关心病人并以良好的医德医风为座右铭,以为病人服务为最高宗旨。并长期在医,教,研三方面同时努力。以下简略介绍主要工作。

1. 心血管外科临床工作。

何教授本人长期坚持临床实践,共完成数千例心脏直视手术(冠心病搭桥,心脏瓣膜成形或置换术,先天性心脏病根治术,主动脉大血管手术等),效果达国际水平。在国际上首创桡动脉搭桥新方案(GWHE Protocol)及四联征带瓣跨环补片等手术的新方法。何教授于1995年率先于香港大学开展了桡动脉搭桥手术。是亚洲最早作桡动脉搭桥的少数手术医生之一,并应新加坡卫生部邀请在国立心脏中心进行桡动脉搭桥手术。在1995年后并在国内多间医院首次开展冠心病搭桥,若干复杂先心病,及大血管手术。



2. 心血管研究工作。

在完成临床工作同时,何教授领导的研究组在心肌保护内皮细胞功能及冠心病搭桥移植物生物学这两个研究领域上长期居于国际领先地位。首次对冠脉移植血管依生物学特性分为I,II,III 型。此分型已被国际上较为广泛地采用,并被引用为“He’s Classification”。 首次提出血管节段性反应的理论。 此研究的一部份已连图解一起引用在国际经典专著Sabiston & Spencer “Surgery of the Chest(胸部外科学)”(1985-1986页),对国际动脉化冠心病搭桥术的发展及降低死亡率和并发症做出了贡献。

此外,何教授系统地分析研究了影响冠心病搭桥术以及心脏瓣膜替换术的生存率的因素,于90年代即总结成多篇论文,发表在心血管外科的主要国际杂志如J Thorac Cardiovasc Surg 和Ann Thoracic Surg上。



3. 在国外出版英文专著。

作为唯一一名主编在国外出版英文专著Arterial Grafting for Coronary Artery Bypass Surgery (动脉化冠状动脉旁路移植外科学)。由Springer公司出版了2版(现已翻译成中文出版)。这是由中国人主编,组织世界各发达国家(美国,欧洲等)专家参编的第一部冠状动脉旁路移植外科学的专著。美国 Heart Surgery Forum评价此专著为“The best single source of information on all arterial grafting…”。 世界著名心脏外科医生, 美国得克萨斯心脏研究所 (Texas Heart Institute) 所长Dr. Denton Cooley在他为此专著写的前言中写道“很多著名的心脏外科医生和心血管科学家为此书作出了贡献,并由何博士汇总主编。何博士在冠心病动脉化搭桥方面发表了大量的论文(huge body of literature)。他对这一方面的广泛的经验及深入的理解为他赢得了全球性的声望”。

4. 美国胸外科学会首批华人常任(Active)会员。

由于在临床手术和研究两方面的工作,何国伟教授于1999年被要求非常严格的美国胸外科学会 (American Association for Thoracic Surgery) 选为常任(Active)会员,是继吴英恺院士被选为名誉会员以来的首批大中华地区的华人会员。



5. 新加坡“全 球 华 人 专 业 人 士 网 络”顾问。

何国伟教授与其它著名华人一起被聘为新加坡“全球华人专业人士网络” (简称”华专网” http://www.networkchinese.com/aboutus.html) 顾问。网络顾问团成员为:丁肇中,王倬,王赓武,田长霖(已故),田刚,李政道,许智宏,刘遵义,邹至庄,张系国,何国伟,陈省身,余森美,林延龄,徐立之,高锟,梁秉中,萧荫堂,崔琦,路甬祥,蔡南海。

6. SCI 论文。

在国际杂志及国内外会议上发表论文以及报告(摘要) 数百篇(绝大多数为第一作者或负责作者),包括285篇SCI论文及报告(摘要)。 165篇论文由美国Pub Med索引,其中4篇论文发表于影响因子(IF)为15.202的“循环”, 103篇发表于IF > 3.0 , 130篇发表于IF > 2.0的国际期刊。 论文的总影响因子大于560。何教授ISI的h – 指数 (h – Index) 为32。 至2013年6月,何教授论文的SCI引用次数为3,405次。



7. 国际杂志的编委会委员及审稿。

何国伟教授是国际心脏外科权威杂志美国“胸外科年刊”及“世界外科杂志”,“心脏外科论坛”等10余个国际杂志的编委会委员以及“循环(Circulation”), “循环研究(Circulation Research)”等约20 个国际杂志的特约审稿人;中国心血管病研究杂志副主编;国际杂志胸心外科公开杂志Open Journal of Cardiovascular and Thoracic Surgery (http://www.bentham.org/open/toctsj/EBM.htm)的主编。

8. 学会工作。

何国伟教授于2007年后担任中国心血管外科医师协会特邀委员(常委),天津市心胸外科学会常委。

9. 研究基金评审工作。

何国伟教授是英国,法国,瑞士,澳大利亚,新加坡,香港等国家(地区)国家级研究基金评审委员会的评审委员。



10. 国家奖评审工作。

何国伟教授多次担任国家科学技术奖自然科学奖基础医学评审委员,国家科技部国际科学技术合作奖评审委员。

11. 获得的研究基金(项目)。

何国伟教授共获得15项重要研究项目的研究资助包括美国波特兰及香港政府研究资助局资助以及中国国家科技部、国家自然科学基金委,天津市科委及滨海新区的研究资助。回国以前获得美国波特兰及香港政府研究资助局等多个重要研究项目的研究资助。2007年后获中国国家科技部、国家自然科学基金委,天津市科委及滨海新区的多个研究项目资助。

12. 组织并主持(主席)美国,香港等地的国际学术大会。

何国伟教授曾多次组织并主持(主席)美国,香港等地的国际学术大会。如美国实验生物学大会(1998,旧金山)及世界药理大会内皮细胞分会的主席。



13. 担任博士研究生导师,博士后研究员导师。

何国伟教授长期在香港大学,香港中文大学,南开大学,美国俄勒冈医学及科技大学担任博士研究生导师,博士后研究员导师。

14. 荣获自然科学奖。

何国伟教授(第一完成人)荣获天津市2012自然科学奖一等奖。项目名称:血管内皮功能及失调的机制及在心血管转化医学中意义的基础研究。






GuoWei He


Name:Guowei He(Vice-president)

Specialty:Center for Basic Medical Research/Cardiovascular Surgery

Title:Chief Physician

Degree:Doctor


Professor Guo-Wei HE, MD, PhD ((Monash), DSc (Monash) is Vice President and Chief of Department of Cardiovascular Surgery II, as well as Director, Center for Basic Medical Research, TEDA International Cardiovascular Hospital (from October, 2007-), Tianjin,China.



Professor He currently also holds Clinical Professor of Surgery, Department of Surgery, Oregon Health and Science University, Portland, OR, U.S.A. and Chair Professor, Zhejiang University as well as Hangzhou Normal University, China.

Previously, Professor He was Chair Professor of Cardiothoracic Surgery, Department of Surgery, University of Hong Kong & Honorary Consultant Cardiac Surgeon, The Grantham Hospital, Hospital Authority, Hong Kong and then Research Professor of Surgery & Director, Cardiovascular Surgical Research Laboratory, Department of Surgery, The Chinese University of Hong Kong, Hong Kong and Professor of Surgery at Nankai University. He was also Director, Cardiovascular Research, Starr Academic Center, Providence Heart Institute, Portland OR, U.S.A.



Professor HE was Cardiac Surgeon-in-Charge at Fu Wai Hospital, Beijing in 1980s. He was awarded Master of Medicine degree at Peking Union Medical College in 1982. He was sent by Fu Wai Hospital to the Royal Children’s Hospital, Melbourne, Australia to study neonatal and pediatric cardiac surgery and St. Vincent Hospital for coronary artery bypass surgery. Professor He, apart from his busy clinical schedule, obtained PhD (in Surgery) degree from Monash University in 1989. Later on, by his scientific work, he was awarded Doctor of Science (DSc) degree by Monash. Professor He was a senior registrar at the Cardiothoracic Surgery Unit, Royal Prince Alfred Hospital, Sydney from 1989.

Professor He went to North America in 1990. He accepted a position at Dallas as Director of Cardiovascular Research, and then Director, Cardiovascular Research, Starr Academic Center for Cardiac Surgery, Providence Heart Institute, Portland OR, U.S.A. from 1994 until recently. Even when he was Chair Professor at the University of Hong Kong, he was still holding that position as an honorary Director. Since September, 2001, he is appointed Clinical Professor of Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Oregon Health and Science University, Portland, OR, U.S.A.



In his career as a cardiac surgeon in the past more than 30 years, Professor He performed thousands of open heart operations including coronary artery bypass grafting (CABG), valve repair and replacement, surgery for congenital heart diseases, and surgery for the great vessel diseases. Professor He first classified the arterial grafts for CABG and is world-widely cited as “He Classification”. Professor He developed a new method for CABG using arterial grafts, particularly the radial artery (University of Hong Kong Protocol or GWHE Protocol) and was one of the first cardiac surgeons using the radial artery for CABG in Asia. He also developed a new surgical method to repair the right ventricular outflow tract stenosis by using an autologous monocusp patch. Professor He started to operate on acute dissection of the aorta in 1995, and was one of the cardiac surgeons doing this kind of operations in 1990s in China. Professor He performed a large number of valve replacement with superior results. Professor He has been helping a number of hospitals in China to start heart surgery for some complex congenital heart diseases and CABG, and successfully performed the first operation such as CABG, TAPVC, Complete AV canal, and exec. in some provinces or hospitals.

Apart from his clinical practice as a Senior Cardiac Surgeon, Professor He also devoted to both basic and clinical science in the past 30 years and had multiple contributions in vascular biology and more recently, genomic and proteomic studies in heart diseases in Chinese patients. He obtained multiple RGC grants and recently grants from the Ministry of Science & Technology and National Science Foundation, China.



Professor He is the first Chinese elected to be an “Active Member” of American Association for Thoracic Surgery – the most strictly selective organization for this specialty.

Professor He is (or was) a member of editorial board for more than 10 international journals including The Annals of Thoracic Surgery (U.S.A.), World Journal of Surgery (U.S.A.) , and The Heart Surgery Forum (U.S.A.). He is Editor-in-Chief of The Open Cardiovascular and Thoracic Surgery Journal, (by Bentham Science Publishers, ISSN:1876-5335 http://www.bentham.org/index.htm ), Deputy Editor-in-Chief,Chinese Cardiovascular Research, Beijing, exec.

Professor He has organized a number of international conferences and was invited to organize or to be the Chair of a number of basic science symposia on endothelial research such as Experimental Biology (FASEB, 1998, San Francisco) and International Union for Pharmacology (IUPHAR) Beijing, 2006.



Professor He has edited “Arterial grafting for coronary artery bypass Surgery” (1st and 2nd Edition). The book is written by world-experts in this field who have made original contributions in this clinical and research field. The book has been published by Springer-Verlag Singapore Ltd and is evaluated as the world “best single source of information for coronary artery bypass surgery using arterial grafts”, by the Chief-Editor of “Heart Surgery Forum” (U.S.A.). The book is forworded by Denton A Cooley, MD, one of the World-most-renowned cardiac surgeons from Houston, Texas, USA. Dr. Cooley stated that “Many renowned cardiac surgeons and cardiovascular researchers have contributed to this volume, which has been compiled by Guo-Wei He, MD, PhD, DSc. Dr. He has published a huge body of literature about arterial grafting in CABG, and his extensive experience in, and deep understanding of, this subject has earned him global recognition.

Professor He has 295 SCI (Science Citation Index, U.S.A.) -indexed publications and 181 full papers including editorials indexed by “Pub Med” including multiple papers in “Circulation (IF:15.202). The IF (of the journal) of his papers published is > 15.202 of 4 papers; IF > 7.0 of 6 papers; IF > 5.0 of 16 papers; IF > 3.0 of 104 papers; and IF > 2.0 of more than 150 papers. The h-Index of Professor He’s publications is 34. In the majority of those papers, he is the corresponding or first author. The total SCI citations are 3,787 up to May, 2015.



The St. Vincent Medical Foundation has established “Albert Starr – Guo-Wei He International Post-doctoral Research Fellowship” to support young scientists for advanced research training at the Cardiovascular Research Laboratory, Starr Academic Center, Providence Heart & Vascular Institute, Portland, OR, USA. Eight young post-doctoral scientists from the Mainland of China have been awarded this fellowship. Professor He’s PhD students are now worked in a number of countries and several of them have become professors in USA, Hong Kong, and China Mainland universities.

Professor He’s scientific contributions are as follows:

• First systematically identified a pathway apart from nitric oxide or prostacyclin mechanism – a cellular hyperpolarization mechanism in the human arteries and veins;

• First systematically identified the reactivity and related receptor functions in the endothelium and smooth muscle of the human arteries used as coronary artery bypass surgery as grafts and classified those vessels that formed the found stone for the comprehensive use of the arteries in coronary bypass surgery;



• First discovered the adverse effect of potassium ions and the effect of other ions on the hyperpolarization-related endothelial function in the coronary and pulmonary circulation that has important implications in heart-arrest related surgical procedures and may open a new era of the methods to preserve heart and lung in the future;

• Apart from these experimental physiology and pharmacology studies, he also systematically studied and identified the risk factors for coronary artery bypass surgery and for the long-term survival after valve replacement surgery.

• In recent years, Professor He’s research interest is focused on the genetic and proteomic studies in cardiovascular diseases.

As stated by Professor Louis J Ignarro, the 1998 Nobel Laureat in Physiology & Medicine: “Professor He’s work has established him as one of the few surgical-scientists in the world. His work is grounded in basic science and he has contributed numerous fundamental observations and insights to that body of knowledge,…”



Professor He has received a number of science awards as follows:

1. First Prize, 2012 Tianjin Natural Science Award (1st Contributor);

2. 2013 China Medical Science and Technology Award (3rd Class) (1st Contributor);

3. 2012 Tianjin Binhai New Area Science & Technology Progress Award (2nd Prize), (1st Contributor);

4. Awardee of a number of Research Grants from Research Grants Council, Hong Kong, Am. Heart Assoc., St. Vincent Medical Foundation, U.S.A.




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