专家介绍---张平




  姓名:张平

  科室:再生医学中心

  职称:教授,博士生导师

  学历:博士后


  张平,教授,博士生导师,泰达国际心血管病医院再生医学中心主任,2013年入选天津市“用三年时间引进千名高层次人才”。从事干细胞分化及转化研究多年,并深入探索机械加载和药物在再生医学等领域中的应用。采用骨质疏松、骨关节炎、股骨头坏死、乳腺癌骨转移等实验动物模型,关节机械刺激和研发的药物能有效地诱导骨髓来源的干细胞分化,使破骨细胞减少,成骨细胞增多,并降低巨噬细胞及其相关的炎性反应,达到良好的疗效。此外,在高血压、心肌梗死、肥胖、糖尿病、老年痴呆等领域,建立动员内源性干细胞在再生医学应用的新策略。

  教育和工作经历

  2016.5-至今 泰达国际心血管病医院再生医学中心 主任,教授

  2013.6-至今: 天津医科大学人体解剖与组织胚胎学系 主任、教授、博士生导师天津医科大学生物医学工程学院 教授

  2006-2014年: 美国印第安纳大学生物医学工程学系 研究教授

  2005-2006年: 美国印第安纳大学 生物医学工程学系 博士后

  2001-2005年: 美国印第安纳大学医学院心血管研究中心 博士后

  1998-2001年: 北京协和医学院基础学院及中国医学科学院基础医学研究所副教授、硕士研究生导师

  1992-1998年: 北京协和医学院基础学院及中国医学科学院基础医学研究所 讲师

  1989-1992年: 北京大学医学部(北京医科大学) 研究生


  专业杂志的编委

  1. Open Journal of Orthopedics (OJO) (2011 – present)

  2. Journal of Applied Mechanical Engineering (JAME) (2011- present)

  3. Modern Plastic Surgery (MPS) (2011- present)

  4. Journal of Biomechanical Engineering (2011- present)


  专业协会的会员

  1. 矫形外科研究学会 (Orthopaedic Research Society; ORS)

  2. 美国骨和矿物质协会(American Society for Bone and Mineral Research; ASBMR)

  3. 国际华人骨研学会 (International Chinese Musculoskeletal Research Society; ICMRS)

  4. 天津市医药学专家协会内分泌医师专家委员会 副主委

  5. 中国生物医学工程学会纳米医学与工程分会 专家

  6. 天津生物医学工程学会 理事

  7. 天津生物医学工程学会医疗科研资源专业委员会 副主委

  8. 中国解剖学会和天津解剖学会


  在中国的科研基金

  1. 国家自然科学基金面上项目 Salubrinal通过调节内质网应激治疗骨质疏松的机制研究 81572100 (68.4万)2016年1月 – 2019年12月 (主申请人)

  2. 天津市应用基础与前沿技术研究计划(重点项目):Wnt3a/LRP5信号通路在机械刺激治疗骨关节炎的机制研究 (20万)14JCZDJC36500 2014年4月 – 2017年3月 (主申请人)

  3. 天津市人才基金 (200万)2013年6月 – 2018年2月


  在美国的科研基金

  1. 美国国家卫生研究院 (NIH/NIAMS)R01AR52144 (合作申请人),机械刺激和骨(332.6万美元),2006年2月10日- 2019年8月31日

  2. 美国国防部 (U.S Department of Defense) DOD PR100092 (合作申请人),新药在骨质疏松和骨折的研制开发(261.5万美元),2011年8月22日- 2015年8月21日

  3. 美国国家卫生研究院 (NIH/NIAMS) R03AR55322 (主申请人),机械刺激促进骨的延长(22.5万美元),2008年8月4日- 2011年11月30日

  4. 美国 FORCE 智能骨科治疗仪的开发(3.5万美元)(主申请人),2014年7月1日- 2016年6月30日

  5. 美国State of Indiana A70-5-0791036 (合作申请人),治疗脊髓损伤所致骨质疏松的新方法(12万美元),2014年7月1日- 2016年6月30日

  6. 美国国家航空和宇宙航行局(NASA) NNX10AE37G (合作申请人),骨在太空的应激反应(30万美元),2010年4月1日- 2013年3月31日

  7. 美国国家卫生研究院 (NIH/NIAMS) R01AR50008 (合作申请人),成骨细胞在三维胶原基质培养中的机械反应(125万美元),2004年4月12日- 2009年3月31日

  8. RSFG22-950-58 (主申请人),长骨的纵形生长(3.5万美元),2008年1月1日- 2010年12月31日


  发表论文

  1. Li, X., Yang, J., Liu, D., Li, J., Niu, K., Feng, S., Yokota, H., Zhang, P*. Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis. Sci Rep 2016;6:24668.

  2. Liu, D., Li, X., Li, J., Yang, J., Yokota, H., Zhang, P*. Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing. Bone 2015; 81:620-631.

  3. Li, X.M., Yang, H., Li, D.Q., Zhang, P., Ma, Q.T., Zhai, L.D. Muscular structure at the male bladder outlet examined with successive celloidin-embedded slices. Urology 2015; 85:629-635.

  4. Yokota, H., Hamamura, K., Chen, A., Dodge, T.R., Tanjung, N., Abedinpoor, A., Zhang, P*. Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells. BMC Musculoskel Dis 2013; 14:197.

  5. Chen, A.B., Zhang, P., Yokota, H. Evaluating treatment of osteoporosis using particle swarm on a bone remodeling mathematical model. IET Systems Biol. 2013; 7:231-242.

  6. Hamamura, K., Zhang, P., Zhao, L., Shim, J.W., Chen, A., Dodge, T.R., Wan, Q., Shih, H., Na, S., Lin, C.C., Sun, H.B., Yokota, H. Knee loading reduces MMP13 activity in the mouse cartilage. BMC Musculoskel Dis 2013; 14:312.

  7. Rhodes, S.D., Wu, X., He, Y., Chen, S., Yang, H., Staser, K.W., Wang, J., Zhang, P., Jiang, C., Yokota, H., Dong, R. Peng, X., Yang, X., Murthy, S., Azhar, M., Mohammad K.S., Xu, M., Guise, T.A., Yang, F.C. Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model. J Bone Miner Res 2013; 28:2476-2489.

  8. Zhang, P., Hamamura, K., Jiang, C., Zhao, L., Yokota, H. Salubrinal promotes wound healing in rat femurs. J Bone Miner Metab 2012; 30:568-579.

  9. Zhang, P., Yokota, H. Elbow loading promotes longitudinal bone growth of the ulna and the humerus. J Bone Miner Metab 2012; 30:31-39.

  10. Zhang, P., Jiang, C., Yokota, H. Lengthening of hind limbs with local administration of insulin-like growth factor 2. J Chin Med Assoc 2012; 75:494-500.

  11. Zhang, P., Yokota, H. Knee loading stimulates healing of mouse bone wounds at a femoral neck. Bone 2011; 49:867-872.

  12. Zhang, P., Jiang, C., Ledet, E., Yokota, H. Loading- and unloading-driven regulation of phosphorylation of eIF2α. Biol Sci Space 2011; 25(1):3-6.

  13. Chen, A., Zhang, P., Duan Z., Wang, G., Yokota, H. Modeling the molecular transportation of subcutaneously injected salubrinal. Biomedical Engineering and Computational Biology 2011; 3:25-32.

  14. Zhang, P., Hamamura, K., Turner, C.H., Yokota, H. Lengthening of mouse hindlimbs with joint loading. J Bone Miner Metab 2010; 28:268-275.

  15. Zhang, P., Liang, Y., Kim, H., Yokota, H. Evaluation of a pig femoral head osteonecrosis model. J Orthop Surg Res 2010; 5:15.

  16. Chen, A., Hamamura, K., Zhang, P., Chen, Y., Yokota, H. Systems Analysis of bone remodeling as a homeostatic regulator. IET Syst Biol 2010; 4:52-63.

  17. Hirasawa, H., Jiang, C., Zhang, P., Yang, F.C., Yokota, H. Mechanical Stimulation Suppresses Phosphorylation of eIF2α and PERK-Mediated Responses to Stress to the Endoplasmic Reticulum. FEBS Lett 2010; 584:745-752.

  18. Zhang, P., Turner, C.H., Yokota, H. Joint loading-driven bone formation and signaling pathways predicted from genome-wide expression profiles. Bone 2009; 44: 989-998.

  19. Zhang, P., Hamamura, K., Yokota, H., Malacinski, GM. Potential applications of pulsating joint loading in sports medicine. Exerc Sport Sci Rev 2009; 37:52-56.

  20. Tian, Z., Ma, D., Zhang, P., Yokota, H. Osteogentic mechanism of different stimulation and sports training. China Sport Science Technology 2009; 45:115-120.

  21. Zhang, P., Malacinski, G.M, Yokota, H. Joint loading modality: Its application to bone formation and fracture healing. Brit J Sport Med 2008; 42:556-560.

  22. Zhang, P., Yokota, H. Knee loading promotes longitudinal bone growth in both young and adult mice. Bone 2008; 43:S42-43.

  23. Wang, Y., Thomas, D., Zhang, P., Yokota, H., Yang, L. Whole field strain measurement on complex surfaces by digital speckle pattern interometry. Mater Eval 2008; 507-512.

  24. Zhang, P., Hamamura, K., Yokota, H. A brief review of bone adaptation to unloading. Geno Prot Bioinfo 2008; 6:4-7.

  25. Hamamura, K., Zhang, P., Yokota, H. IGF2-Driven PI3 Kinase and TGFβ Signaling Pathways in Chondrogenesis. Cell Biol Int 2008; 32: 1238-1246.

  26. Zhang, P., Sun, Q., Turner, C.H., Yokota, H. Knee loading acclerates bone healing in mice. J Bone Miner Res 2007; 22: 1979-1987.

  27. Zhang, P., Tanaka, S., Sun, Q., Turner, C.H., Yokota, H. Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading. J Bone Miner Metab 2007; 25:383-391.

  28. Zhang, P., Yokota, H. Effects of surgical holes in mouse tibiae on bone formation induced by knee loading. Bone 2007; 40:1320-1328.

  29. Zhang, P., Su, M., Liu, Y., Hus, A., Yokota, H. Knee loading dynamically alters intramedullary pressure in mouse femora. Bone 2007; 40: 538-543.

  30. Yang, L., Zhang, P., Liu, S., Samala, P., Yokota, H. Measurement of strain distributions in mouse femora with 3D-Digital Speckle Pattern Interferometry. Opt Laser Eng 2007; 45:843-851.

  31. Zhang, P., Tanaka, S., Jiang, H., Su, M., Yokota, H. Diaphyseal bone formation in murine tibiae in response to knee loading. J Appl Physiol 2006; 100: 1452-1459.

  32. Zhang, P., Su M., Tanaka S, Yokota H. Knee loading causes diaphyseal cortical bone formation in murine femurs. BMC Musculoskel Dis 2006; 73: 1-12.

  33. Su, M., Jiang, H., Zhang, P., Liu, Y., Wang, E., Hus, A., Yokota, H. Load-driven molecular transport in mouse femur with knee-loading modality. Ann Biomed Eng 2006; 34: 1600-1606.

  34. Su, M., Zhang, P., Yokota, H., Malacinski, G.M. Development of a knee-loading joint supporter for potential use in preventing bone loss during spaceflight/aging. Biol Sci Space 2005; 19 (4): 245-249.

  35. Yossef, E.A., Zhang, P., Rogers, P., Tremble, P., Rokovich, J., Johnstone, B.H., March, K.L., Hou, D. Enhancing myocardial plasmid expression by retrograde coronary venous delivery. Catheter Cardio Inte 2005; 65(4): 528-534.

  36. Hou, D., Youssef, E.A., Brinton, T.J., Zhang, P., Rogers, P., Price, E.T, Yeung, AC, Johnstone, B.H., Yock, P.G., March, K.L. Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation 2005; 112:I150-I156.

  37. Hou, D., Narciso, H., Kamdar, K., Zhang, P., Barclay, B., March, K.L. Stent-based nitric oxide delivery reducing neointimal proliferation in a porcine carotid overstretch injury model. Cardiovasc Inter Rad 2005; 28(1): 60-65.

  38. Youssef, E.A., Zhang, P., Ropgers, P., Johnstone, B., March, K.L., Hou, D. Fate of endothelial progenitor cells after intramyocardial and intracoronary. delivery; Implications for current clinical trials. Circulation 2004; 110(17):S507.

  39. Youssef, E.A., Zhang, P., Rogers, P., Tremble, P., Rokovich, J., Johnstone, B., March, K.L., Hou, D. Comparing two modalities of myocardial gene delivery: Percutaneous retrograde coronary venous delivery and intramyocardial injection. Molecular Therapy 2004; 9(1): S357-358.

  40. Hou, D., Narciso, H., Kamdar, K., Zhang, P., March, K.L. Dose-response study of the med-aspire nitric oxide-eluting stent in a porcine iliac noninjury model. Am J Cardiol 2003; 92(6A): 97L.

  41. Zhang, P., March, K.L., Hou, D. Physical training and cardioprotection. Chin J Sports Medicine 2003; 22(4): 378-382.

  42. Hou, D., Zhang, P., Marsh, A.E., March, K.L. Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstreth. J Chin Med Assoc 2003; 66(11): 637-642.


  参加50余次国际学术大会并十余次大会报告。

  1. 李杰,李心乐,刘大全,张平*。Salubrinal attenuates bone loss in a mouse model of unloading-induced osteoporosis。2016年中国解剖学会第32届学术年会。

  2. 高哲,李心乐,张平*。Salubrinal在骨关节炎治疗中的形态学观察。2016年中国解剖学会第32届学术年会。(大会报告)

  3. 郭嘉露,李杰,李心乐,张平*。机械加载有效降低高盐高脂导致的高血压。2016年中国解剖学会第32届学术年会。

  4. 刘大全,李杰,杨爽,李心乐,张平*。Treatment of hip osteoporosis by a selective inhibitor of eIF2α de-phosphorylation。2016年中国解剖学会第32届学术年会。

  5. 谭念,李心乐,翟丽东,张平*。机械加载对绝经后肥胖的降脂作用。2016年中国解剖学会第32届学术年会。(大会报告)

  6. 王钊楠,李杰,李心乐,张平*。机械加载改善慢性脑缺血后的学习记忆能力。2016年中国解剖学会第32届学术年会。(大会报告)

  7. 杨爽,李心乐,张平*。机械加载对乳腺癌骨转移治疗的形态学观察。2016年中国解剖学会第32届学术年会。

  8. 赵灿,李心乐,王俊艳,张平*。机械加载对小鼠乳腺癌肺转移和肿瘤血管生成的抑制作用。2016年中国解剖学会第32届学术年会。

  9. Li, D., Li, J., Li, X., Yokota, H., Zhang, P*. Knee loading enhances vessel remodeling and bone healing in a rat femoral head osteonecrosis model. 37th Ann Meeting ASBMR 2015

  10. Li, X., Li, J., Zhang, P*. Spine mechanical loading attenuates bone loss in a mouse model of postmenopausal osteoporosis. 2nd ICMRS-ASBMR International Musculoskeletal Research Conference 2015.

  11. Liu, D., Li, J., Yang, S., Li, X., Zhang, P*. Salubrinal stimulates bone healing in a rat femoral head osteonecrosis. 2nd ICMRS-ASBMR International Musculoskeletal Research Conference 2015.

  12. 刘大全,李杰,李心乐,张平*。关节机械加载治疗股骨头坏死的疗效观察。2015年中国解剖学会第31届学术年会。

  13. 李杰,李心乐,张平*。Salubrinal通过抑制破骨细胞发育治疗骨质疏松的形态学观察。2015年中国解剖学会第31届学术年会。

  14. 杨静,李心乐,张平*。关节机械加载减轻骨关节炎损伤的组织学观察。2015年中国解剖学会第31届学术年会。

  15. 刘大全,李杰,杨静,李心乐,张平*。脉冲式关节机械加载通过调节骨髓干细胞分化治疗股骨头坏死。2015年中华医学会第十六次全国物理医学与康复学学术会议 。

  16. 李杰,李心乐,张平*。脉冲性机械加载治疗骨质疏松的疗效观察。2015年中华医学会第十六次全国物理医学与康复学学术会议。(大会报告).

  17. 杨静,李心乐,张平*。脉冲式关节机械加载治疗骨关节炎的疗效观察。2015年中华医学会第十六次全国物理医学与康复学学术会议。

  18. 张平*,李心乐,刘素娟,郑璐,王春妹。关节机械加载治疗骨质疏松中巨噬细胞系的关键作用。2014年第九届COA国际学术大会。(大会报告).

  19. Zhang, P., Chen, A., Yokota, H. Salubrinal inhibits differentiation of osteoclasts in unloaded mice. 35th Ann Meeting ASBMR 2013.

  20. Wan, Q., Cho, E., Zhang, P., Yokota, H., Na, S. Rho GTPases control nuclear localization of beta-catenin and TCF/LEF activity in osteoblasts under flow. 35th Ann Meeting ASBMR 2013.

  21. Zhang, P., Chen, A., Dodge, T., Tanjung, N., Zhang, Y., Fuqua, C., Yokota, H. Salubrinal regulates differentiation of mesenchymal stem cells from ovariectomized mice. 59th Ann Meeting ORS 2013 (大会报告).

  22. Rhodes, SD, He Y., Wu, X., Zhang, P., Chen, S., Jiang, C., Yokota, H., Yang, X, Peng, X., Murthy, S, Mohammad KS, Guise TA, Yang, FC. Hyperactive transforming growth factor-beta1 signaling potentiates fracture non-union in neurofibromatosis type 1. 34th Ann Meeting ASBMR 2012 (大会报告).

  23. Zhang, P., Yokota, H. Bone remodeling is linked to vessel remodeling in femoral head and neck. 34th Ann Meeting ASBMR 2012.

  24. Zhang, P., Chen, S., Rhodes, SD, He Y., Zhang, P., Yang, X., Yuan, J., Li, X, Jing L., Yang, FC. GDC-0941 is sufficient to prevent unloading induced bone loss in a NF1 murine model. 58th Ann Meeting ORS 2012 (大会报告).

  25. Zhang, P., Chen, S., He Y., Rhodes, SD, Zhang, P., Yang, X., Yuan, J., Jing L., Yang, FC. Genetic deletion of osteopontin restores unloading mediated bone loss in a NF1 murine model. 33th Ann Meeting ASBMR 2011 (大会报告).

  26. Rhodes, SD, He Y., Wu, X., Chen, LH, Zhang, P., Chen, S., Jiang C., Yokota, H., Peng, X., Mohammad KS, Guise TA, Yang, FC. Targeting the TGF-β/Smad Pathway in Neurofibromatosis Type 1 Skeletal Defects. 33th Ann Meeting ASBMR 2011 (大会报告).

  27. Zhang, P., Yokota, H. Loading and Unloading-Driven Regulation of Phosphorylation of eIF2α. 57th Ann Meeting ORS 2011.

  28. Zhang, P., Yokota, H. Knee loading promotes bone healing in femoral head osteonecrosis. 32nd Ann Meeting ASBMR 2010 (大会报告).

  29. Zhang, P., Yokota, H. Adaptation of the growth plate to knee loading. 56th Ann Meeting ORS 2010.

  30. Yokota, H., Jiang, C., Zhang, P. Translational Regulation in Mechanical Loading. Biomedical Engineering Society Ann Meeting 2009.

  31. Zhang, P., Yokota, H. Rat models for total and partial osteonecrosis of the femoral head. 31st Ann Meeting ASBMR 2009.

  32. Zhang, P., Yokota, H. Salubrinal stimulates anabolic responses in mouse femora. 55th Ann Meeting ORS 2009.

  33. Zhang, P., Liang, Y., Kim, H., Yokota, H. Analysis of blood circulation in a pig osteonecrosis model of the femoral head. 55th Ann Meeting ORS 2009.

  34. Chen, A., Chen, Y., Zhang, P., Yokota, H. A bone-remodeling process as a feedback regulator. 55th Ann Meeting ORS 2009.

  35. Zhang, P., Yokota, H. Bone length was differentially promoted in the left and right hindlimbs with knee loading and local administration of IGF-2. 30th Ann Meeting ASBMR M476 2008.

  36. Zhang, P., Yokota, H. Elbow loading stimulates longitudinal bone growth of humerus and ulna. 54th Ann Meeting ORS 2008 (大会报告).

  37. Zhang, P., Yokota, H. Knee loading promotes longitudinal bone growth in both young and adult mice. International Conference on Osteoporosis and Bone Research 2008.

  38. Zhang, P., Yokota, H. Joint loading and its application in bone healing. International Osteoporosis Conference: Bone and Joint Decade 2007.

  39. Zhang, P., Yokota, H. Joint loading modality. The Eighth International Bone Fluid Flow Workshop 2007.

  40. Zhang, P., Sun, Q, Turner, C.H., Yokota, H. Knee loading stimulates wound healing in mouse femura. 29th Ann Meeting ASBMR M526 2007.

  41. Zhang, P., Cui, M., Yang, D., Yokota, H. Tibial bone formation with novel ankle loading. 53rd Ann Meeting ORS 2007.

  42. Zhang, P., Tanaka, S., Yokota, H. Bone formation in mouse femoral neck with Knee-Loading. 28th Ann Meeting ASBMR 2006 (大会报告).

  43. Zhang, P., Jackson, M.E., Yokota H. Knee-loading driven wound healing in mouse tibia. 28th Ann Meeting ASBMR 2006.

  44. Song, H., Liu, Y., Zhang, P., Wek, R., Yokota, H. Regulation of ATF4 expression in osteoblasts in response to mechanical stimulation. 28th Ann Meeting ASBMR 2006.

  45. Zhang, P., Su, M., Cheng, T., Yokota, H. Femoral bone formation response to knee loading. 52nd Ann Meeting ORS 1754, 2006.

  46. Su, M., Zhang, P., Cheng, T., Yokota, H. Load-driven molecular transport in response to knee loading. 52nd Ann Meeting ORS 1027, 2006.

  47. Zhang, P., Tanaka, S., Jiang, H., Su, M., Yokota, H. Loading frequency-dependent enhancement of bone formation in mouse tibia with knee-loading modality. J Bone Miner Res 2005; 20: S134-135.

  48. Su, M., Zhang, P., Huang, Y., Yokota, H. Monitoring load-driven fluid flow in 3D matrix using microparticles. J Bone Miner Res 2005; 20: S350.

  49. Youssef, E.A., Zhang, P., Rogers, P., Tremble, P., Rokovich, J., Johnstone, B., March, K.L., Hou, D. Comparing two modalities of myocardial gene delivery: Percutaneous retrograde coronary venous delivery and intramyocardial injection. Molecular Therapy 2004; 9: S357-358.

  50. Youssef, E.A., Zhang, P., Ropgers, P., Johnstone, B., March, K.L., Hou, D. Fate of endothelial progenitor cells after intramyocardial and intracoronary delivery; Implications for current clinical trials. American Heart Association 2004; 110: III-507. (大会报告).

  51. Hou, D., Narciso, H., Kamdar, K., Zhang, P., March, K.L. Dose-response study of the med-aspire nitric oxide-eluting stent in a porcine iliac noninjury model. Am J Cardiol 2003; 92: 97L.




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